BPC-157

Tissue repair · By Preptide Pro editorial team · Last updated 2026-11-03

BPC-157 is a tissue repair peptide, and it is not FDA-approved. A synthetic 15-amino-acid peptide derived from a gastric protein sequence. Research is mostly in animals, looking at tendon, gut and wound healing.

Not FDA-approved

Chemistry (PubChem)

PubChem CID	9941957
CAS number	137525-51-0
Molecular formula	C62H98N16O22
Molecular weight	1419.5 g/mol
Other names	Bpc-157, Bpc 157, Bepecin, Bpc 15, pl-10, PLD-116, PL-14736, RefChem:121176

The human evidence, study by study

Very little human research exists. A 2026 systematic review (PMID 42885452) found three human studies with 30 participants in total. All were uncontrolled or very small, and the reviewers rated the certainty of evidence very low.

Study	Design	People	Route	Reported	Source
Knee pain	Retrospective chart review, no control group	16	Injection into the knee	Most reported improvement	PMID 34324435
Interstitial cystitis	Retrospective pilot	12	Into the bladder	Symptom improvement	Summarized in PMID 42885452
IV safety pilot	Prospective pilot	2	Intravenous	No adverse events reported	PMID 40131143

What the review concludes

The studies reported no treatment-related adverse events, but 30 people in uncontrolled studies is far too few to establish safety or benefit. The review concluded BPC-157 should not be used clinically outside regulated trials (PMID 42885452).

Animal and cell research

Most BPC-157 research is in animals and cells. Animal results don’t show that something works or is safe in people. The “How much research” table below lists the latest PubMed papers.

FAQ

Does BPC-157 work for tendon injuries in humans?

No controlled human trials have tested it, so there is no evidence either way in people.

Were side effects reported in human studies?

None were reported across 30 people, which is too few to draw conclusions.

How can I follow new BPC-157 research?

The research search in Preptide Pro finds new PubMed papers with links. You can also do the vial math.

Is BPC-157 FDA-approved?

Not FDA-approved. No matching NDA or BLA was found in openFDA (Drugs@FDA).

How much research is there on BPC-157?

PubMed lists 237 records for “BPC-157 OR "body protection compound"”, of which 0 are tagged as human clinical trials.

Most recent PubMed records
Recent study	Journal	Date
Efficient Expression of Small Molecule Bioactive Peptides in Bacillus licheniformis.	Appl Biochem Biotechnol	2026 Nov
Investigational Peptides in Orthopaedic Practice: Evidence, Safety, and Patient Counseling for BPC-157, Thymosin Beta-4, and TB-500.	J Am Acad Orthop Surg	2026 Oct 27
Human evidence for BPC-157 in orthopaedic and regenerative medicine: a systematic review of efficacy and safety.	Acta Orthop Belg	2026 Oct 8
Possibilities for Cytoprotective Liver Therapy, Stable Gastric Pentadecapeptide BPC 157, and Standard Agents-A Narrative Review.	Pharmaceuticals (Basel)	2026 Oct 1
Case Report: Regenerative peptides for Inferior alveolar nerve injury: a narrative review with hypothesis-generating three clinical cases.	Front Oral Health	2026

Sources

This is general research information, not medical advice. Check with a clinician before using any compound.