NAD+
Cellular health · By Preptide Pro editorial team · Last updated
NAD+ is a cellular health peptide, and it is not FDA-approved. A coenzyme found in every cell and involved in energy metabolism. It is not a peptide. Research looks at NAD+ precursors and how levels change with aging.
Not FDA-approvedChemistry (PubChem)
| PubChem CID | 5892 |
|---|---|
| CAS number | 53-84-9 |
| Molecular formula | C21H27N7O14P2 |
| Molecular weight | 663.4 g/mol |
| Other names | nadide, coenzyme I, beta-NAD, Codehydrase I, Codehydrogenase I, nicotinamide adenine dinucleotide, diphosphopyridine nucleotide, Cozymase I |
Is NAD+ FDA-approved?
Not FDA-approved. No matching NDA or BLA was found in openFDA (Drugs@FDA).
How much research is there on NAD+?
PubMed lists 723 records for “"nicotinamide adenine dinucleotide" supplementation”, of which 32 are tagged as human clinical trials.
| Recent study | Journal | Date |
|---|---|---|
| In vitro NAD+ supplementation increases CD4+ and CD8+ T cell function in people with HIV. | HIV Med | 2026 Nov 2 |
| Nuclear NAD(+) promotes innate immune memory by inhibiting KDM5A-dependent histone demethylation. | Sci Immunol | 2026 Oct 30 |
| ADP-ribose induces neuronal ferroptosis through ENT2-mediated nucleotide rewiring. | Nat Chem Biol | 2026 Oct 28 |
| Biomaterials Targeting Mitochondrial NAD(+) Metabolism for Tissue Regeneration. | Adv Healthc Mater | 2026 Oct 26 |
| Divergent Immunometabolic Regulatory Networks Mediated by FOXO3 During Musculoskeletal Aging: Implications for Tissue-Adapted Precision Therapeutics. | Cell Biochem Biophys | 2026 Oct 24 |
Sources
This is general research information, not medical advice. Check with a clinician before using any compound.