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LL-37

Immune · By Preptide Pro editorial team · Last updated

LL-37 is a immune peptide, and it is not FDA-approved. The only human cathelicidin antimicrobial peptide. Studied for its role in immunity, skin and wound biology.

Not FDA-approved

Chemistry (PubChem)

PubChem CID16198951
CAS number154947-66-7
Molecular formulaC205H340N60O53
Molecular weight4493 g/mol
Other namesLL-37, ropocamptide, Cap-18, cathelicidin LL-37, CAP18, Antibacterial peptide LL-37, antimicrobial peptide LL-37, LL-37 antibacterial peptide

Is LL-37 FDA-approved?

Not FDA-approved. No matching NDA or BLA was found in openFDA (Drugs@FDA).

How much research is there on LL-37?

PubMed lists 3,171 records for “LL-37 cathelicidin”, of which 60 are tagged as human clinical trials.

Most recent PubMed records
Recent studyJournalDate
Targeted delivery of antimicrobial peptide LL-37 via ferritin fusion improves antibacterial and anti-inflammatory outcomes in a murine sepsis model.Int J Biol Macromol2026 Nov
Combinatorial therapy of LL-37 and ADSCs accelerates diabetic wound repair by orchestrating NRROS-mediated crosstalk between TGF-β/SMAD and hippo/TEAD1 axes.Cytokine2026 Nov
Chicken cathelicidin-3 protected mice from avian pathogenic Escherichia coli infection mediated by triggering chemokine CCL3 pathway.Vet Res2026 Oct 6
Chimeric IL-6/4R-LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis.Adv Sci (Weinh)2026 Oct
Human neuronal cells SH-SY5Y as an in vitro model to study Neospora caninum infection and innate immune modulation.Vet J2026 Oct

Sources

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